Innate – Communicable Diseases Research

A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response

Article

Published on 2022-12-212022-11-15
Journal: Journal of theoretical biology
[Category] COVID19(2023년), SARS, 변종, 치료제,

Innate immune mechanisms of mRNA vaccines

Article

Published on 2022-11-082022-11-16
Journal: Immunity
[Category] Fulltext, MERS, 유전자 메커니즘,

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19
[DOI] 10.1128/spectrum.01604-22 PMC 바로가기

Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection

Article

Published on 2022-10-012022-11-15
Journal: Inflammation
[Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

[키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation vaccine candidate vaccine candidates vaccine for COVID-19 vaccine.. viral disease viral evolution virus viruses
[DOI] 10.1007/s10753-022-01651-y PMC 바로가기

Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant

Article

Published on 2022-09-212022-11-15
Journal: Clinical microbiology reviews
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome advance antibodies antibody-based therapies booster characterized Community coronavirus counter COVID-19 disease severity driving effective strategy Effectiveness entry inhibitors Entry mechanism enzyme evade faster fusion inhibitors fusion pathway highlighting immune Immune escape immune evasion Immunity immunotherapies Infection inhibitor inhibitors Innate mitigate monoclonal motif mutated natural infection omicron pan-CoV vaccines Perspective raising resistance. resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 variant SARS-CoV-2 viral Spread T cell T cell response the SARS-CoV-2 the spike protein Transmissibility Transmission Vaccine vaccine-induced antibody Vaccines variant variants virus
[DOI] 10.1128/cmr.00014-22 PMC 바로가기

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease

주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다

Review

Published on 2022-09-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors Toll-like receptors. understanding variants of concern Variation viral infection viral infections VOCs
[DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review

Molecular mechanisms involved in pathogenicity of SARS-CoV-2: Immune evasion and implications for therapeutic strategies

Article

Published on 2022-09-012022-11-16
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] COVID19(2023년), SARS, 변종,

On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus

바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화

Article

Published on 2022-08-152022-09-11
Journal: Journal of hazardous materials
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Stress response. Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus
[DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article

Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients

SARS-CoV-2에 감염된 개인 및 백신 수혜자의 자연 살해 세포 매개 ADCC

Article

Published on 2022-08-012022-09-11
Journal: European Journal of Immunology
[Category] COVID19(2023년), SARS, 진단, 치료법,

[키워드] adaptive immune system ADCC ADCC activity anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines antibodies antibody antibody-dependent cellular cytotoxicity BNT162b2 BNT162b2 vaccine caused CD107a cells characterized collected correlated COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibodies cross-reactive antibody degranulation Endemic expected expression focus global pandemic identify immune response immune responses individual infected individuals Innate Innate immunity killing less natural NK cell NK cells nucleocapsid Protein recipient Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2-infected individual second vaccination serum sample serum samples significantly significantly higher These data Trigger Vaccine vaccine. while
[DOI] 10.1002/eji.202149470 PMC 바로가기 [Article Type] Article

Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity

Research

Published on 2022-07-252022-10-05
Journal: Nature Immunology
[Category] 변종,